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After you have been taking allopurinol regularly for several months, the attacks may stop completely. The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. Case reports have suggested that thiazide diuretics may increase the risk of allopurinol-induced hypersensitivity reactions, especially in patients with renal insufficiency. The product of methylation, 2-amino-6-methylthiopurine, is also substantially less active and less toxic than Thioguanine and its formation is likewise unaffected by the presence of allopurinol. The following information includes only the average doses of allopurinol.

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